Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS 3q rearrangements in myeloid malignancies
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Atlas of Genetics and Cytogenetics in
Oral presentation Homozygous deletions are often seen in cancer as a means of inactivating tumour suppressor genes. However, such deletions can also result from genome instability and as such probably represent passenger events that do not contribute to carcinogenesis. These passenger deletions are often associated with known regions of genomic fragility (fragile sites). We have analysed approx...
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INTRODUCTION Structural rearrangements of chromosome 3q have been described in approximately 2% of patients with acute myeloid leukemia. Breakpoints are mainly located in the 3q21 and 3q26 regions but may occur elsewhere on chromosome 3. To determine the relationship between these breakpoints and the hematological parameters, including outcome of these patients, we analysed data from newly diag...
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تاریخ انتشار 2011